Proteomics in prevention and treatment of post-myocardial infarction heart failure diseases with traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20240815.601
- Author:
Feng-Rong ZHANG
1
;
Ying ZHANG
2
;
Ji-Cheng YANG
2
;
Xian-Yu LI
2
;
Hong-Jun YANG
1
Author Information
1. Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:English Abstract
- Keywords:
heart failure;
myocardial infarction;
proteomics;
traditional Chinese medicine
- MeSH:
Humans;
Proteomics;
Myocardial Infarction/drug therapy*;
Heart Failure/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Animals
- From:
China Journal of Chinese Materia Medica
2024;49(22):6008-6018
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction(MI) is a cardiovascular disease with high disability and mortality rates in clinical practice, which can subsequently develop into complications such as heart failure(HF) or cardiac rupture. Proteomics can track changes in relevant functional molecules during the occurrence and progression of diseases from an overall, molecular, systematic, and flux perspectives. Utilizing proteomic techniques to deeply explore the functional targets, molecular mechanisms, and network effects of MI and HF can aid in early diagnosis, early warning, and drug treatment of these diseases. In recent years, significant progress has been made in the prevention and treatment of HF following MI using traditional Chinese medicine(TCM), particularly in elucidating the complex mechanisms of action through proteomic techniques. This article systematically reviewed research on the intervention mechanisms of TCM compound prescriptions and their active ingredients in HF after MI, and explored related in vivo pathways. Additionally, it discussed the role of proteomics in protein biomarker discovery, post-translational modifications of proteins, protein-protein interactions, spatial proteomics, and more, with the aim of advancing the deep application of proteomic techniques in the prevention and treatment of cardiovascular diseases with TCM.
