Advances in roles of Parabacteroides distasonis and its regulation by traditional Chinese medicines.
10.19540/j.cnki.cjcmm.20240611.708
- Author:
Dan LONG
1
;
Meng QIN
1
;
Pei-Peng CHEN
1
;
Xin HUANG
2
;
Ya-Ting CAO
2
;
Ai-Ling YIN
2
;
Yue-Yue CHEN
2
;
Hai-Dan WANG
3
;
Yun-Ke GUO
3
;
Xuan WANG
4
;
Hai-Jian SUN
5
;
Jin-Jun SHAN
6
;
Wei ZHOU
1
Author Information
1. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009, China.
2. Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210001, China.
3. Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
4. Department of Rheumatology and Immunology, Tongji Hospital of Tongji University Shanghai 200065, China.
5. Wuxi Medical College, Jiangnan University Wuxi 214028, China.
6. Medical Metabolomics Center,Nanjing University of Chinese Medicine, Jiangsu Key Laboratory of Pediatric Respiratory Disease,Institute of Pediatrics, Nanjing University of Chinese Medicine Nanjing 210000, China.
- Publication Type:English Abstract
- Keywords:
Parabacteroides distasonis;
intestinal microbiota;
pharmacological effects;
traditional Chinese medicine
- MeSH:
Humans;
Gastrointestinal Microbiome/drug effects*;
Medicine, Chinese Traditional;
Animals;
Bacteroidetes;
Drugs, Chinese Herbal/pharmacology*
- From:
China Journal of Chinese Materia Medica
2024;49(22):5988-5997
- CountryChina
- Language:Chinese
-
Abstract:
Parabacteroides distasonis is a gram-negative bacterium initially isolated from a clinical specimen in the 1930s. The strain was re-classified to form the new genus Parabacteroides in 2006. P. distasonis can regulate intestinal barrier function and plays a key role in immune response and metabolic regulation of bodies. Traditional Chinese medicine(TCM) is closely related to the intestinal microbiota. Polysaccharides, saponins, and other ingredients of TCM can treat diseases by interacting with P. distasonis, but the specific mechanisms underlying these processes are still unclear, requiring further exploration. This study reviewed the roles and related mechanisms of P. distasonis in inflammatory-immune diseases, metabolic diseases, cardiovascular disease, neuropsychiatric diseases, cancer, and other diseases and summarized the relevant research results of TCM to prevent and treat diseases by regulating P. distasonis. This study provides a reference for subsequent exploration of P. distasonis and research on the interaction between TCM and intestinal microbiota.
