Research progress on indirect action and mechanism of traditional Chinese medicine based on gut-gut microbiota-target organ talks.
10.19540/j.cnki.cjcmm.20240722.401
- Author:
Yu-Jing ZHAI
1
;
Xiao-Xuan WANG
1
;
Xue WANG
1
;
Ya-Jie DOU
1
;
Yan-Yan XU
1
;
Yu-Bo LI
1
Author Information
1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
- Publication Type:English Abstract
- Keywords:
gut microbiota;
indirect action;
mechanism;
organ talks;
traditional Chinese medicine;
visceral manifestation theory
- MeSH:
Gastrointestinal Microbiome/drug effects*;
Humans;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/pharmacology*;
Animals;
Kidney/metabolism*;
Liver/drug effects*;
Brain/drug effects*;
Lung/drug effects*
- From:
China Journal of Chinese Materia Medica
2024;49(22):5977-5987
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) has been treating diseases for thousands of years and still holds an irreplaceable position in modern disease treatment. The composition of TCM is complex, and its mode of action features multi-pathway and multi-target characteristics, making its pharmacological actions and mechanisms complicated. The principles and mechanisms of TCM have always been a hot topic among scholars from various fields. Increasingly, studies show that indirect action plays an important role in the mode of action of TCM. The gut microbiota is regarded as a new invisible metabolic organ, and TCM can treat diseases by targeting the gut microbiota, thereby exerting an indirect effect across organs based on the connection between organs. Therefore, this paper summarized the indirect regulatory mechanisms of TCM based on the visceral manifestation theory and the organ axis of modern medical research. It also discussed the talks and communication mechanisms between the gut microbiota and target organs such as the liver, brain, kidney, and lungs, providing references for research on the mechanisms of indirect action of TCM and the development of innovative drugs.
