Research progress on the role of extracellular vesicles in the repair of skeletal muscle membrane injury.
- Author:
Yi-Long LIU
1
;
Ying WU
1
Author Information
- Publication Type:English Abstract
- MeSH: Extracellular Vesicles/physiology*; Humans; Muscle, Skeletal/physiology*; Cell Membrane/physiology*; Animals; Regeneration/physiology*; Exocytosis/physiology*; Endocytosis/physiology*; Cell Communication/physiology*
- From: Acta Physiologica Sinica 2025;77(5):956-968
- CountryChina
- Language:Chinese
- Abstract: The timely and efficient repair of the plasma membrane in skeletal muscle cells following injury is critical for maintaining cellular function and tissue integrity. Extracellular vesicles (EVs) play a pivotal role in this process through multi-level mechanisms. This review systematically summarizes the generation, secretion, and multifunctional roles of EVs in the repair of skeletal muscle plasma membrane damage: (1) removing damaged membrane fragments and cellular debris via endocytosis and exocytosis to maintain plasma membrane stability; (2) fusing with the injured plasma membrane to supply essential components for membrane repair and restore membrane integrity; and (3) serving as a vital mediator of intercellular communication, transmitting repair signals, promoting intercellular interactions, and orchestrating multi-level responses to facilitate tissue regeneration and functional recovery. Additionally, this article explores the potential applications of EVs in the treatment of exercise-induced injuries and muscular diseases, aiming to provide theoretical insights and novel strategies for future research and EV-based therapeutic approaches.
