Research progress on the role of dopamine system in regulating hippocampal related brain functions.
- Author:
Jing REN
1
;
Wei-Yi MO
1
;
Ling WANG
1
;
Guang-Jian NI
1
;
Jia-Jia YANG
1
Author Information
- Publication Type:English Abstract
- MeSH: Hippocampus/physiology*; Dopamine/physiology*; Humans; Animals; Receptors, Dopamine D2/physiology*; Memory/physiology*; Signal Transduction/physiology*; Neurodegenerative Diseases/physiopathology*
- From: Acta Physiologica Sinica 2025;77(5):893-904
- CountryChina
- Language:Chinese
- Abstract: Dopamine, as a catecholamine neurotransmitter widely distributed in the central nervous system, is involved in physiological functions such as motivation, arousal, reinforcement, and movement through various dopamine signaling pathways. The hippocampus receives dopaminergic neuron projections from regions such as the ventral tegmental area, locus coeruleus, and substantia nigra. Through D1-like and D2-like receptors, dopamine exerts significant regulatory effects such as spatial navigation, episodic memory, fear, anxiety, and reward. This review mainly summarizes the research progress on the functions of dopamine in the hippocampus from aspects including the sources of dopamine, receptor distribution and function, and the association of hippocampal dopamine system dysregulation with neurodegenerative diseases. The aim is to provide insights into the involvement of the dopamine system in hippocampal functions and the diagnosis and treatment of related diseases.
