The MAP1 family: a new perspective for exploring unknown functions.

Author: Qing WANG ¹ ; Mei LIU ¹ ; Zhang-Ji DONG ¹
Author Information

1. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
Publication Type:English Abstract
MeSH: Humans; Animals; Microtubule-Associated Proteins/classification*; Neurons/cytology*; Neurodegenerative Diseases/physiopathology*; Microtubules/physiology*; Cytoskeleton/physiology*
From: Acta Physiologica Sinica 2025;77(5):876-892
CountryChina
Language:Chinese
Abstract: As an important part of the cytoskeleton, microtubules play a crucial role in many cellular processes, such as cell division, intracellular transport, and maintaining cell morphology. The MAP1 family is an important family of microtubule-associated proteins, which includes three members: MAP1A, MAP1B, and MAP1S. These proteins are widely involved in the dynamic regulation of the cytoskeleton and play a key role in the development and function of the central nervous system, especially in the development and function of neurons. This study reviews the research progress of the MAP1 family, mainly focusing on the structure and function of MAP1 family members, and paying particular attention to their roles in neuronal development and regeneration, regulatory mechanisms, and neurodegenerative diseases.