Research progress in the role of HCN channels in Alzheimer's disease.

Author: Xiao-Juan LI ¹ ; Bo ZHENG ² ; Ping LAN ² ; Wen-Xin ZHANG ² ; Yi-Peng LI ² ; Zhi HE ²
Author Information

1. The Second People's Hospital of China Three Gorges University, Yichang 443000, China.
2. Basic Medical College, China Three Gorges University, Yichang 443002, China.
Publication Type:English Abstract
MeSH: Humans; Alzheimer Disease/physiopathology*; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology*; Animals; Amyloid beta-Peptides/metabolism*
From: Acta Physiologica Sinica 2025;77(5):867-875
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is the commonest neurodegenerative disease that causes memory decline, cognitive dysfunction and behavior disorders in the aged people. Primary pathological hallmarks of AD include amyloid-β (Aβ), neurofibrillary tangles (NFTs), gliosis, and neuronal loss. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have important physiological functions, especially in aspects of controlling the resting membrane potential, pacemaker activity, memory formation, sleep and arousal. This article reviews the structure, distribution, regulation of HCN channels and the role of HCN channels in the pathological mechanisms of AD, aiming to provide drug therapeutic targets for the prevention and treatment of AD.