Research progress of the interaction between RAAS and clock genes in cardiovascular diseases.
- Author:
Rui-Ling MA
1
;
Yi-Yuan WANG
1
;
Yu-Shun KOU
1
;
Lu-Fan SHEN
1
;
Hong WANG
1
;
Ling-Na ZHANG
1
;
Jiao TIAN
1
;
Lin YI
1
Author Information
- Publication Type:English Abstract
- MeSH: Humans; Renin-Angiotensin System/genetics*; Cardiovascular Diseases/genetics*; CLOCK Proteins/physiology*; Animals
- From: Acta Physiologica Sinica 2025;77(4):669-677
- CountryChina
- Language:Chinese
- Abstract: The renin-angiotensin-aldosterone system (RAAS) is crucial for regulating blood pressure and maintaining fluid balance, while clock genes are essential for sustaining biological rhythms and regulating metabolism. There exists a complex interplay between RAAS and clock genes that may significantly contribute to the development of various cardiovascular and metabolic diseases. Although current literature has identified correlations between these two systems, the specific mechanisms of their interaction remain unclear. Moreover, the interaction patterns under different physiological and pathological conditions need further investigation. This review summarizes the synergistic roles of the RAAS and clock genes in cardiovascular diseases, explores their molecular mechanisms and pathophysiological connections, discusses the application of chronotherapy, and highlights potential future research directions, aiming to provide novel insights for the prevention and treatment of related diseases.
