Cellular differential impact of the Rap1 on atherosclerosis.
- Author:
Shan-Shan SONG
1
;
Hui-Ru YANG
1
;
Xiao-Li YI
1
;
Jun YU
2
;
Chuan-Ming XU
1
Author Information
- Publication Type:English Abstract
- MeSH: Humans; Atherosclerosis/metabolism*; rap1 GTP-Binding Proteins/physiology*; Animals; Cell Differentiation; Cell Adhesion; Cell Proliferation
- From: Acta Physiologica Sinica 2025;77(3):483-492
- CountryChina
- Language:Chinese
- Abstract: Cardiovascular diseases are the leading cause of mortality, posing a significant threat to human health due to the high incidence rate. Atherosclerosis, a chronic inflammatory disease, serves as the primary pathological basis for most such conditions. The incidence of atherosclerosis continues to rise, but its pathogenesis has not been fully elucidated. As an important member of the small GTPase superfamily, Ras-association proximate 1 (Rap1) is an important molecular switch involved in the regulation of multiple physiological functions including cell differentiation, proliferation, and adhesion. Rap1 achieves the utility of the molecular switch by cycling between Rap1-GTP and Rap1-GDP. Rap1 may influence the occurrence and development of atherosclerosis in a cell-specific manner. This article summarizes the potential role and mechanism of Rap1 in the progression of atherosclerosis in different cells, aiming to provide new therapeutic targets and strategies for clinical intervention.
