Roles and mechanisms of TRIM family proteins in the regulation of bone metabolism.
- Author:
Jing YANG
1
;
Rui-Qi HUANG
1
;
Ke XU
1
;
Mian-Mian YANG
1
;
Xue-Jie YI
1
;
Bo CHANG
2
;
Ting-Ting YAO
1
Author Information
- Publication Type:English Abstract
- MeSH: Humans; Ubiquitin-Protein Ligases/physiology*; Bone and Bones/metabolism*; Animals; Tripartite Motif Proteins/physiology*; Osteoclasts/metabolism*; Osteoblasts/metabolism*; Signal Transduction/physiology*; Osteogenesis/physiology*
- From: Acta Physiologica Sinica 2025;77(3):472-482
- CountryChina
- Language:Chinese
- Abstract: Tripartite motif-containing (TRIM) family proteins are crucial E3 ubiquitin ligases that have garnered significant attention for their regulatory roles in bone metabolism in recent years. This article reviews the function and regulatory mechanisms of TRIM family proteins in bone metabolism, focusing on their dual roles in bone formation and resorption. It also provides a detailed analysis of signaling pathways and molecular mechanisms by which TRIM family members regulate the activities of osteoblasts and osteoclasts. Research findings suggest that modulating the expression or activity of TRIM family proteins could be beneficial for treating bone diseases such as osteoporosis. This review highlights the molecular mechanisms of TRIM family members in bone physiology and pathology, aiming to provide theoretical basis and scientific guidance for developing novel therapeutic strategies for bone diseases.
