Therapeutic potential of ion channel modulation in Alzheimer's disease.
- Author:
Bing HUANG
1
;
Cheng-Min YANG
2
;
Zhi-Cheng LU
1
;
Li-Na TANG
1
;
Sheng-Long MO
2
;
Chong-Dong JIAN
2
;
Jing-Wei SHANG
2
Author Information
- Publication Type:English Abstract
- MeSH: Alzheimer Disease/therapy*; Humans; Ion Channels/physiology*; Oxidative Stress; Animals; Amyloid beta-Peptides/metabolism*; Synaptic Transmission; Calcium/metabolism*
- From: Acta Physiologica Sinica 2025;77(2):327-344
- CountryChina
- Language:Chinese
- Abstract: Alzheimer's disease (AD), a prototypical neurodegenerative disorder, encompasses multifaceted pathological processes. As pivotal cellular structures within the central nervous system, ion channels play critical roles in regulating neuronal excitability, synaptic transmission, and neurotransmitter release. Extensive research has revealed significant alterations in the expression and function of ion channels in AD, implicating an important role of ion channels in the pathogenesis of abnormal Aβ deposition, neuroinflammation, oxidative stress, and disruptions in calcium homeostasis and neural network functionality. This review systematically summarizes the crucial roles and underlying mechanisms of ion channels in the onset and progression of AD, highlighting how these channel abnormalities contribute to AD pathophysiology. We also discuss the therapeutic potential of ion channel modulation in AD treatment, emphasizing the importance of addressing multifactorial nature and heterogeneity of AD. The development of multi-target drugs and precision therapies is proposed as a future direction of scientific research.
