Research progress of the dopamine system in neurological diseases.
- Author:
Yu-Qi NIU
1
;
Jin-Jin WANG
1
;
Wen-Fei CUI
1
;
Peng QIN
1
;
Jian-Feng GAO
1
Author Information
- Publication Type:English Abstract
- MeSH: Humans; Dopamine/metabolism*; Nervous System Diseases/physiopathology*; Parkinson Disease/physiopathology*; Receptors, Dopamine/metabolism*; Dopaminergic Neurons/physiology*; Dopamine Plasma Membrane Transport Proteins/metabolism*; Alzheimer Disease/physiopathology*; Schizophrenia/physiopathology*; Animals
- From: Acta Physiologica Sinica 2025;77(2):309-317
- CountryChina
- Language:Chinese
- Abstract: The etiology of nervous system diseases is complicated, posing significant harm to patients and often resulting in poor prognoses. In recent years, the role of dopaminergic system in nervous system diseases has attracted much attention, and its complex regulatory mechanism and therapeutic potential have been gradually revealed. This paper reviews the role of dopaminergic neurons, the neurotransmitter dopamine, dopamine receptors and dopamine transporters in neurological diseases (including Alzheimer's disease, Parkinson's disease and schizophrenia), with a view to further elucidating the disease mechanism and providing new insights and strategies for the treatment of neurological diseases.
