The regulatory effect and mechanism of PGC-1α on mitochondrial function.
- Author:
Song-Hua NAN
1
;
Chao-Jie PENG
1
;
Ying-Lin CUI
2
Author Information
- Publication Type:English Abstract
- MeSH: Humans; Mitochondria/metabolism*; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/physiology*; Animals; Energy Metabolism/physiology*; Neurodegenerative Diseases/physiopathology*; Autophagy/physiology*; Transcription Factors/physiology*; Metabolic Diseases/physiopathology*; Cardiovascular Diseases/physiopathology*
- From: Acta Physiologica Sinica 2025;77(2):300-308
- CountryChina
- Language:Chinese
- Abstract: Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a core member of the PGC-1 family and serves as a transcriptional coactivator, playing a crucial regulatory role in various diseases. Mitochondria, the main site of cellular energy metabolism, are essential for maintaining cell growth and function. Their function is regulated by various transcription factors and coactivators. PGC-1α regulates the biogenesis, dynamics, energy metabolism, calcium homeostasis, and autophagy processes of mitochondria by interacting with multiple nuclear transcription factors, thereby exerting significant effects on mitochondrial function. This review explores the biological functions of PGC-1α and its regulatory effects and related mechanisms on mitochondria, providing important information for our in-depth understanding of the role of PGC-1α in cellular metabolism. The potential role of PGC-1α in metabolic diseases, cardiovascular diseases, and neurodegenerative diseases was also discussed, providing a theoretical basis for the development of new treatment strategies.
