Advances in application of small-molecule compounds in neuronal reprogramming.
- Author:
Zi-Wei DAI
1
;
Hong LIU
1
;
Yi-Min YUAN
1
;
Jing-Yi ZHANG
1
;
Shang-Yao QIN
1
;
Zhi-Da SU
1
Author Information
1. Department of Neurobiology, College of Basic Medicine, Key Laboratory of Molecular Neurobiology of Ministry of Education, Naval Medical University, Shanghai 200433, China.
- Publication Type:English Abstract
- MeSH:
Humans;
Cellular Reprogramming/drug effects*;
Neurons/cytology*;
Animals;
Transcription Factors;
Small Molecule Libraries/pharmacology*;
Nerve Regeneration
- From:
Acta Physiologica Sinica
2025;77(1):181-193
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal reprogramming is an innovative technique for converting non-neuronal somatic cells into neurons that can be used to replace lost or damaged neurons, providing a potential effective therapeutic strategy for central nervous system (CNS) injuries or diseases. Transcription factors have been used to induce neuronal reprogramming, while their reprogramming efficiency is relatively low, and the introduction of exogenous genes may result in host gene instability or induce gene mutation. Therefore, their future clinical application may be hindered by these safety concerns. Compared with transcription factors, small-molecule compounds have unique advantages in the field of neuronal reprogramming, which can overcome many limitations of traditional transcription factor-induced neuronal reprogramming. Here, we review the recent progress in the research of small-molecule compound-mediated neuronal reprogramming and its application in CNS regeneration and repair.
