Research advances on the structure, function, and related diseases of TREK-1 potassium channels.
- Author:
Xiao-Ling LI
1
;
Yang LI
2
;
Hong ZHANG
1
Author Information
1. School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Shanghai Institute of Pharmacy, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:English Abstract
- MeSH:
Potassium Channels, Tandem Pore Domain/genetics*;
Humans;
Animals;
Cardiovascular Diseases/physiopathology*;
Autoimmune Diseases/metabolism*;
Central Nervous System Diseases/physiopathology*
- From:
Acta Physiologica Sinica
2024;76(6):1043-1055
- CountryChina
- Language:Chinese
-
Abstract:
Two-pore-domain potassium channels (K2P) family is widely expressed in many human cell types and organs, which has important regulatory effect on physiological processes. K2P is sensitive to a variety of chemical and physical stimuli, and they have also been critically implicated in transmission of neural signal, ion homeostasis, cell development and death, and synaptic plasticity. Aberrant expression and dysfunction of K2P channels are involved in a range of diseases, including autoimmune, central nervous system, cardiovascular disease and others. The scope of this review is to give a detailed overview of the structure, function, pharmacological regulation, and related diseases of TREK-1 channels, a member of the K2P family.
