Advances in inhibitory ion channel glycine receptors.
- Author:
Xu-Ke PANG
1
;
Si CHEN
1
;
Xiang-Xian MA
1
;
Yi-Nuo XU
2
;
Wei-Jie BAI
3
;
Chong-Lei FU
1
;
Gui-Chang ZOU
4
Author Information
1. Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
2. Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China.
3. Department of Neurosurgery, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China.
4. Department of Clinical Psychology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250117, China.
- Publication Type:English Abstract
- MeSH:
Receptors, Glycine/physiology*;
Humans;
Animals;
Central Nervous System Diseases/metabolism*
- From:
Acta Physiologica Sinica
2024;76(6):908-916
- CountryChina
- Language:Chinese
-
Abstract:
Glycine receptors (GlyRs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. GlyRs are essential for maintaining visual, auditory, sensory and motor functions, and abnormalities in its structure and function can lead to various neurological disorders. This review aims to provide an extensive analysis of the structure, function and regulatory mechanisms of GlyRs, and evaluate its role in various central nervous system diseases. Ultimately, this review will provide theoretical support for the development of novel drugs specifically targeting GlyRs.
