Incidence, mortality, and burden of Parkinson's disease in China: A time-trend analysis and comparison with the global burden based on Global Burden of Disease Study 2021.
10.1097/CM9.0000000000003839
- Author:
Fan GAO
1
;
Xiaoyu CHENG
1
;
Junyi LIU
2
;
Yinlian HAN
1
;
Chengjie MAO
1
;
Chongke ZHONG
3
;
Chunfeng LIU
1
Author Information
1. Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004 China.
2. Department of Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215125 China.
3. Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
- Publication Type:Journal Article
- Keywords:
Burden;
China;
GBD 2021;
Global Burden of Disease;
Incidence;
Mortality;
Parkinson’s disease;
Trend
- MeSH:
Humans;
Parkinson Disease/mortality*;
China/epidemiology*;
Global Burden of Disease;
Male;
Incidence;
Female;
Disability-Adjusted Life Years;
Middle Aged;
Aged;
Adult;
Quality-Adjusted Life Years;
Aged, 80 and over;
Cost of Illness;
Adolescent;
Pattern Analysis, Machine
- From:
Chinese Medical Journal
2025;138(23):3176-3183
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Parkinson's disease (PD) is a leading cause of death and disability worldwide, and is associated with a significant Global Burden of Disease (GBD). We analyzed the trends in PD incidence, mortality, and disability-adjusted life year (DALY) burden in China, and compared them with global data.
METHODS:Estimates and 95% uncertainty intervals (UIs) for incidence, mortality, DALYs, years lived with disability (YLDs), and years of life lost (YLLs) for PD were extracted from the GBD, Injuries, and Risk Factors Study 2021. We describe the epidemiology of PD at global and Chinese levels, analyze trends in incidence and mortality from 1990 to 2021 by joinpoint regression models, and decompose PD burden according to population size, age structure, and epidemiological changes.
RESULTS:GBD 2021 estimated 508,378 (95% UI: 430,499-592,748) incident cases of PD, 92,035 (95% UI: 75,908-108,133) deaths, and 2,159,514 (95% UI: 1,826,196-2,521,344) DALYs in China, with the higher age-standardized rate (ASR) in incidence, mortality and DALYs than the global levels. The DALY burden of PD in China increased slightly from 1990 to 2021, consistent with the global upward trend. Joinpoint regression analysis indicated that the ASR of incidence in China increased faster than the global average, while the ASR of mortality decreased, with the fastest decline in 2004-2014. Decomposition analysis revealed that men and the middle sociodemographic index (SDI) quintile (32.82%) were responsible for the most significant DALYs, whose changes were primarily driven by population growth and aging.
CONCLUSIONS:The burden of PD showed an overall increasing trend from 1990 to 2021, which was primarily driven by population growth and aging. This study highlights the significant challenges in controlling and managing PD, including the increase in cases and gender differences, which may provide guidance for comprehensive strategies to address the changing profiles of PD in China.
