Exercise-induced angiogenesis and lymphangiogenesis: A potential therapeutic tool to fight aging and disease.
10.1097/CM9.0000000000003831
- Author:
Jizong JIANG
1
;
Yongjun ZHENG
2
;
Rui WANG
1
;
Hao YANG
1
;
Shihui ZANG
1
;
Emeli CHATTERJEE
3
;
Guoping LI
3
;
Dragos CRETOIU
4
;
Cuimei ZHAO
5
;
Junjie XIAO
1
Author Information
1. Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Jiangsu, Nantong 226011, China.
2. Department of Pain Medicine & Department of Rehabilitation Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China.
3. Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
4. Department of Medical Genetics, Carol Davila University of Medicine and Pharmacy, Bucharest 020031, Romania.
5. Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
- Publication Type:Review
- Keywords:
Aging;
Angiogenesis;
Disease;
Exercise;
Lymphangiogenesis
- MeSH:
Humans;
Lymphangiogenesis/physiology*;
Aging/physiology*;
Exercise/physiology*;
Animals;
Neovascularization, Physiologic/physiology*;
Angiogenesis
- From:
Chinese Medical Journal
2025;138(20):2552-2587
- CountryChina
- Language:English
-
Abstract:
Aging is an inevitable, physiological process of the human body, leading to deterioration in bodily function and increased susceptibility to various diseases. Effective endogenous therapeutic strategies for anti-aging and related diseases remain limited. Exercise confers multifaceted benefits to physical health by augmenting osteogenic and myogenic processes, enhancing cardiovascular and nervous system function, and attenuating chronic inflammation. Angiogenesis and lymphangiogenesis play pivotal roles in anti-aging, tissue repair, and immune response modulation, underscoring their potential as therapeutic targets for age-related diseases. Modulating angiogenic and lymphangiogenic pathways may provide a promising strategy for mitigating vascular decline and immune system dysfunction associated with aging. Exercise-induced endogenous angiogenesis and lymphangiogenesis can exert beneficial effects on physiological function, thereby representing a potential therapeutic paradigm for combating age-related decline and diseases. This review offers a thorough summary of the present knowledge regarding angiogenesis and lymphangiogenesis induced by exercise, encompassing the underlying mechanisms and the effects in different organs. In addition, it explores the potential of physical activity as a non-pharmacological intervention for anti-aging strategies and disease management, offering novel insights into the intersection of physical activity, aging, and disease progression.
