Burden and risk factors of stroke worldwide and in China: An analysis from the Global Burden of Disease Study 2021.
10.1097/CM9.0000000000003778
- Author:
Zhengbao ZHU
1
;
Mengyao SHI
2
;
Quan YU
1
;
Jiawen FEI
1
;
Beiping SONG
1
;
Xiaoli QIN
1
;
Lulu SUN
2
;
Yonghong ZHANG
1
Author Information
1. Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Soochow University, Suzhou, Jiangsu 215123, China.
2. Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
- Publication Type:Journal Article
- Keywords:
DALY;
GBD;
Global Burden of Disease Study;
High blood pressure;
Incidence;
Mortality;
Stroke
- MeSH:
Humans;
Stroke/etiology*;
China/epidemiology*;
Risk Factors;
Global Burden of Disease;
Disability-Adjusted Life Years;
Prevalence;
Incidence;
Female;
Quality-Adjusted Life Years;
Male
- From:
Chinese Medical Journal
2025;138(20):2588-2595
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Stroke is the leading cause of death and long-term disability worldwide, including China. This study aimed to provide timely updates on stroke burden and stroke-related risk factors to help improve population-based prevention and control strategies.
METHODS:Based on the Global Burden of Disease study 2021, incidence rate, prevalence rate, mortality rate, and disability-adjusted life-year (DALY) rate were used to estimate stroke burden trend from 1990 to 2021.
RESULTS:In 2021, China had 4.1 million incident stroke cases, 26.3 million prevalent stroke cases, 2.6 million stroke related deaths, and 53.2 million stroke related DALYs, compared to 11.9 million incident stroke cases, 93.8 million prevalent stroke cases, 7.3 million stroke related deaths, and 160.5 million stroke-related DALYs worldwide. In 2021, the top six risk factors contributing to stroke burden were high blood pressure, air pollution, tobacco consumption, dietary risk factors, high low-density lipoprotein cholesterol, and high fasting plasma glucose, both in China and worldwide. From 1990 to 2021, China had significant increases of incidence rate, prevalence rate, mortality rate, and DALY rate for stroke, with estimates of 100.6 (95% uncertainty intervals [UI]: 87.2, 114.1)%, 102.9 (95% UI: 95.5, 110.9)%, 40.0 (95% UI: 14.9, 72.3)% and 15.7 (95% UI: -4.6, 41.2)%, respectively, while global incidence rate, prevalence rate, mortality rate and DALY rate for total stroke showed relatively moderate increases or even decreases, with estimates of 15.0 (95% UI: 12.1,18.0)%, 25.8 (95% UI: 23.7, 28.0)%, -2.6 (95% UI: -10.6, 5.5)%, and -10.7 (95% UI: -17.7, -3.6)%, respectively.
CONCLUSION:Stroke remains a huge disease burden worldwide and in China, and compared to the worldwide China has a significantly higher burden of stroke.
