Global, regional, national incidence, and mortality of breast cancer in older women: A population-based cancer registry data analysis.
10.1097/CM9.0000000000003667
- Author:
Chao LI
1
;
Shaoyuan LEI
2
;
Yan XU
1
;
Yongqiang ZHANG
1
;
Lin LI
1
;
Rongshou ZHENG
3
;
Li DING
1
Author Information
1. Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
2. Department of Evidence-Based Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
3. Office for Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Aging;
Breast cancer;
Incidence;
Mortality;
Older women
- MeSH:
Humans;
Female;
Breast Neoplasms/epidemiology*;
Aged;
Incidence;
Middle Aged;
Registries;
Aged, 80 and over;
Risk Factors
- From:
Chinese Medical Journal
2025;138(22):2917-2924
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The burden of breast cancer for older adults has been rising with the increasing population aging. This study aims to describe the burden of breast cancer in older adults worldwide, analyze the temporal trends for older breast cancer incidence, and assess the socioeconomic inequalities of breast cancer incidence and mortality with human development index (HDI) levels, which will provide valuable information in preventing and controlling the increasing breast cancer burden in older women.
METHODS:The incidence and mortality rates of specific cancer types in older individuals in 2022 were sourced from the Global Cancer Today database. Trends in breast cancer incidence acquired from the Cancer Incidence in Five Continents (CI5) database. HDI and other risk factors were obtained from the United Nations. We used a generalized linear model to estimate the rate ratio and 95% confidence interval (CI) between HDI levels and breast cancer burden in older people.
RESULTS:It was estimated approximately 1,058,466 newly diagnosed breast cancer cases and 383,774 breast cancer deaths in women ≥60 years, accounting for 18.9% and 12.7% of global cancer cases and deaths. The age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) were 172.9 and 57.7 per 100,000, ranking first and second among all cancer incidence and mortality in older women. The highest ASIR and ASMR were four-fold higher than the lowest, with ASIR ranging from a peak of 399.1 per 100,000 in Australia-New Zealand to a low of 90.6 per 100,000 in South Central Asia, and ASMR varying from a high of 118.6 per 100,000 in Melanesia to a low of 28.8 per 100,000 in East Asia. The largest increases in ASIR from 1998-2002 to 2013-2017 were observed in South Korea, China, and Estonia. The corresponding estimated 5-year average percentage changes (EAPC) were 6.01%, 2.89%, and 1.93%, respectively.
CONCLUSIONS:The global burden of breast cancer in older women is increasing fast and varies greatly across countries. Effective prevention strategies are essential to address the increasing breast cancer burden for older women.
