Angiogenesis, signaling pathways, and animal models.
10.1097/CM9.0000000000003561
- Author:
Lasse JENSEN
1
;
Ziheng GUO
2
;
Xiaoting SUN
3
;
Xu JING
4
;
Yunlong YANG
5
;
Yihai CAO
4
Author Information
1. Department of Health, Medical and Caring Sciences, Unit of Diagnostics and Specialist Medicine, Linköping University, Linköping SE-58183, Sweden.
2. Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
3. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vison and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325024, China.
4. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna 17165, Sweden.
5. Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
Angiogenesis;
Intussusception;
Vasculature;
Vasculogenesis
- MeSH:
Animals;
Signal Transduction/physiology*;
Humans;
Neovascularization, Pathologic/physiopathology*;
Neovascularization, Physiologic/physiology*;
Models, Animal;
Angiogenesis
- From:
Chinese Medical Journal
2025;138(10):1153-1162
- CountryChina
- Language:English
-
Abstract:
The vasculature plays a critical role in homeostasis and health as well as in the development and progression of a wide range of diseases, including cancer, cardiovascular diseases, metabolic diseases (and their complications), chronic inflammatory diseases, ophthalmic diseases, and neurodegenerative diseases. As such, the growth of the vasculature mediates normal development and physiology, as well as disease, when pathologically induced vessels are morphologically and functionally altered owing to an imbalance of angiogenesis-stimulating and angiogenesis-inhibiting factors. This review offers an overview of the angiogenic process and discusses recent findings that provide additional interesting nuances to this process, including the roles of intussusception and angiovasculogenesis, which may hold promise for future therapeutic interventions. In addition, we review the methodology, including those of in vitro and in vivo assays, which has helped build the vast amount of knowledge on angiogenesis available today and identify important remaining knowledge gaps that should be bridged through future research.
