Role of noncoding RNA and protein interaction in pancreatic cancer.
10.1097/CM9.0000000000003587
- Author:
Zhang LI
1
;
Tingting ZHANG
;
Xiaojuan YANG
;
Yong PENG
Author Information
1. Center for Molecular Oncology, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
- Publication Type:Review
- Keywords:
Circular RNAs;
Long non-coding RNAs;
Noncoding RNAs;
Pancreatic cancer;
Protein
- MeSH:
Humans;
Pancreatic Neoplasms/metabolism*;
RNA, Untranslated/metabolism*;
Gene Expression Regulation, Neoplastic/genetics*
- From:
Chinese Medical Journal
2025;138(9):1019-1036
- CountryChina
- Language:English
-
Abstract:
Noncoding RNAs (ncRNAs) are a class of RNA molecules with little or no protein-coding potential. Emerging evidence indicates that ncRNAs are frequently dysregulated and play pivotal roles in the pathogenesis of pancreatic cancer. Their aberrant expression can arise from chromosomal abnormalities, dysregulated transcriptional control, and epigenetic modifications. ncRNAs function as protein scaffolds or molecular decoys to modulate interactions between proteins and other biomolecules, thereby regulating gene expression and contributing to pancreatic cancer progression. In this review, we summarize the mechanisms underlying ncRNA dysregulation in pancreatic cancer, emphasize the biological significance of ncRNA-protein interactions, and highlight their clinical relevance. A deeper understanding of ncRNA-protein interactions is essential to elucidate molecular mechanisms and advance translational research in pancreatic cancer.
