Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities.
10.1097/CM9.0000000000003578
- Author:
Zhongyu ZHAO
1
;
Yinrui SUN
2
;
Renhao GUO
1
;
Junzhi LIANG
1
;
Wanlin DAI
1
;
Yutao JIANG
1
;
Yafan YU
3
;
Yuexin YU
4
;
Lixia HE
1
;
Da LI
1
Author Information
1. Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China.
2. Department of Obstetrics and Gynecology, the Second Hospital of Dalian Medical University, Dalian, Liaoning 116021, China.
3. The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
4. Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110003, China.
- Publication Type:Review
- Keywords:
Extracellular vesicles;
Oocyte;
Ovarian diseases
- MeSH:
Humans;
Extracellular Vesicles/physiology*;
Oocytes/cytology*;
Female;
Animals;
Cell Communication/physiology*
- From:
Chinese Medical Journal
2025;138(9):1050-1060
- CountryChina
- Language:English
-
Abstract:
The production of high-quality oocytes requires precisely orchestrated intercellular communication. Extracellular vesicles (EVs) are cell-derived nanoparticles that play a vital role in the transfer of bioactive molecules, which has gained much attention in the field of diagnosis and treatment. Over the past ten years, the participation of EVs in the reproductive processes of oocytes has been broadly studied and has shown great potential for elucidating the intricacies of female reproductive health. This review provides an extensive discussion of the influence of EVs on oocytes, emphasizing their involvement in normal physiology and altered cargo under pathological conditions. In addition, the positive impact of therapeutic EVs on oocyte quality and their role in alleviating ovarian pathological conditions are summarized.
