Advancements in herbal medicine-based nanozymes for biomedical applications.
10.1097/CM9.0000000000003584
- Author:
Mei YANG
1
;
Zhichao DENG
2
;
Yuanyuan ZHU
2
;
Chenxi XU
2
;
Chenguang DING
1
;
Yujie ZHANG
2
;
Mingxin ZHANG
3
;
Mingzhen ZHANG
2
Author Information
1. Department of Organ Procurement and Allocation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
2. School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
3. Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, China.
- Publication Type:Review
- Keywords:
Carbon dots;
Herbal medicine;
Herbzymes;
Nanozymes;
Polyphenol–metal;
Traditional Chinese medicine
- MeSH:
Nanostructures/chemistry*;
Humans;
Herbal Medicine/methods*;
Superoxide Dismutase/chemistry*;
Catalase/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Catalysis;
Glutathione Peroxidase/chemistry*
- From:
Chinese Medical Journal
2025;138(9):1037-1049
- CountryChina
- Language:English
-
Abstract:
Nanozymes are a distinct category of nanomaterials that exhibit catalytic properties resembling those of enzymes such as peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Nanozymes derived from Chinese herbal medicines exhibit the catalytic functions of their enzyme mimics, while retaining the specific medicinal properties of the herb (termed "herbzymes"). These nanozymes can be categorized into three main groups based on their method of synthesis: herb carbon dot nanozymes, polyphenol-metal nanozymes, and herb extract nanozymes. The reported catalytic activities of herbzymes include POD, SOD, CAT, and GPx. This review presents an overview of the catalytic activities and potential applications of nanozymes, introduces the novel concept of herbzymes, provides a comprehensive review of their classification and synthesis, and discusses recent advances in their biomedical applications. Furthermore, we also discuss the significance of research into herbzymes, including the primary challenges faced and future development directions.
