Mitochondrial RNA metabolism, a potential therapeutic target for mitochondria-related diseases.
10.1097/CM9.0000000000003516
- Author:
Tongyue DUAN
1
;
Liya SUN
;
Kaiyue DING
;
Qing ZHAO
;
Lujun XU
;
Chongbin LIU
;
Lin SUN
Author Information
1. Department of Nephrology, The Second Xiangya Hospital of Central South University, Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan 410011, China.
- Publication Type:Review
- Keywords:
Metabolism;
Mitochondria dysfunction;
Mitochondrial RNA;
Mitochondrial diseases;
Modification;
Mutation
- MeSH:
Humans;
Mitochondrial Diseases/therapy*;
RNA, Mitochondrial;
RNA/genetics*;
Mitochondria/genetics*;
Mutation/genetics*;
RNA, Transfer/genetics*;
DNA, Mitochondrial/genetics*
- From:
Chinese Medical Journal
2025;138(7):808-818
- CountryChina
- Language:English
-
Abstract:
In recent years, the roles of mitochondrial RNA and its associated human diseases have been reported to increase significantly. Treatments based on mtRNA metabolic processes and nuclear gene mutations are thus discussed. The mitochondrial oxidative phosphorylation process is affected by mtRNA metabolism, including mtRNA production, maturation, stabilization, and degradation, which leads to a variety of inherited human mitochondrial diseases. Moreover, mitochondrial diseases are caused by mitochondrial messenger RNA, mitochondrial transfer RNA, and mitochondrial ribosomal RNA gene mutations. This review presents the molecular mechanisms of human mtRNA metabolism and pathological mutations in mtRNA metabolism-related nuclear-encoded/nonencoded genes and mitochondrial DNA mutations to highlight the importance of mitochondrial RNA-related diseases and treatments.
