Life's Essential 8 metrics and prognosis in patients with renal insufficiency: Results from the National Health and Nutrition Examination Survey, 2007-2018.
10.1097/CM9.0000000000003461
- Author:
Weihua CHEN
1
;
Guitao XIAO
2
;
Shan DING
3
;
Shanshan SHI
4
;
Yuxiong PAN
2
;
Jiabin TU
2
;
Yanbin ZHANG
2
;
Ying LIAO
2
;
Liling CHEN
2
;
Kaihong CHEN
2
;
Rongchong HUANG
1
Author Information
1. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100053, China.
2. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian 364000, China.
3. Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian 361000, China.
4. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
- Publication Type:Journal Article
- Keywords:
Cardiovascular health;
Cardiovascular mortality;
Life’s Essential 8;
NHANES;
Prognosis;
Renal insufficiency
- MeSH:
Humans;
Male;
Female;
Nutrition Surveys;
Middle Aged;
Renal Insufficiency/physiopathology*;
Aged;
Prognosis;
Adult;
Cardiovascular Diseases/mortality*;
Glomerular Filtration Rate/physiology*;
Proportional Hazards Models
- From:
Chinese Medical Journal
2025;138(21):2824-2831
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The benefits of ideal cardiovascular-health metrics (ICVHMs) in patients with renal insufficiency remain unclear. This study aimed to investigate the associations between ICVHM and prognosis in a renal insufficiency population.
METHODS:The trial enrolled 29,682 participants from the US National Health and Nutrition Examination Survey (NHANES), 2007-2018, with mortality follow-up through December 31, 2019. Participants were divided into three groups based on estimated glomerular filtration rates. Cardiovascular health was assessed using new "Life's Essential 8" metrics. Cox regression analyses based on NHANES data were used to determine the associations between ICVHMs and cardiovascular mortality in patients with renal insufficiency.
RESULTS:During a mean follow-up of 6.58 years, ideal cardiovascular health (hazard ratio [HR] = 0.42; 95% confidence interval [CI]; 0.25-0.70) and ideal health behavior (HR = 0.53; 95% CI; 0.39-0.73) reduced cardiovascular mortality in participants with renal insufficiency. For each one ICVHM increment, a 25% reduction in cardiovascular mortality was recorded (95% CI; 0.69-0.82). When compared with participants with normal renal function, for those with mild renal insufficiency, the HR for cardiovascular mortality gradually decreased from 1.47 (95% CI; 0.85-2.52) in those who had ≤1 ICVHMs to 0.30 (95% CI; 0.12-0.77) in participants who had >6 ICVHMs.
CONCLUSIONS:From an ICVHM perspective, enhanced cardiovascular benefits were observed in individuals with renal insufficiency, coupled with a reduced risk of all-cause mortality. Furthermore, when compared with individuals with normal renal function, increased ICVHMs can mitigate adverse risks associated with renal impairment.
