CAR-based cell therapies for systemic lupus erythematosus.
10.1097/CM9.0000000000003406
- Author:
Yiyang WANG
1
;
Liangjing LU
1
;
Shuang YE
1
;
Qiong FU
1
Author Information
1. Department of Rheumatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai 200127, China.
- Publication Type:Review
- Keywords:
Autoimmune diseases;
CAR T cell;
CAR-based cell therapies;
Systemic lupus erythematosus
- MeSH:
Humans;
Lupus Erythematosus, Systemic/immunology*;
Receptors, Chimeric Antigen/metabolism*;
Immunotherapy, Adoptive/methods*;
Cell- and Tissue-Based Therapy/methods*;
Animals;
T-Lymphocytes/immunology*
- From:
Chinese Medical Journal
2025;138(5):523-530
- CountryChina
- Language:English
-
Abstract:
The remarkable efficacy of chimeric antigen receptor (CAR) T cell therapy in hematological malignancies has provided a solid basis for the therapeutic concept, wherein specific pathogenic cell populations can be eradicated by means of targeted recognition. During the past few years, CAR-based cell therapies have been extensively investigated in preclinical and clinical research across various non-tumor diseases, with particular emphasis in the treatment of autoimmune diseases (ADs), yielding significant advancements. The recent deployment of CD19-directed CAR T cells has induced long-lasting, drug-free remission in patients with systemic lupus erythematosus (SLE) and other systemic ADs, alongside a more profound immune reconstruction of B cell repertoire compared with conventional immunosuppressive agents and B cell-targeting biologics. Despite the initial success achieved by CAR T cell therapy, it is critical to acknowledge the divergences in its application between cancer and ADs. Through examining recent clinical studies and ongoing research, we highlight the transformative potential of this therapeutic approach in the treatment of SLE, while also addressing the challenges and future directions necessary to enhance the long-term efficacy and safety of CAR-based cell therapies in clinical practice.
