Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment.
10.1097/CM9.0000000000003450
- Author:
Tianning HUANG
1
;
Fan LI
1
;
Yiming WANG
1
;
Jian GU
1
;
Ling LU
1
Author Information
1. Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
- Publication Type:Review
- MeSH:
Humans;
Tumor Microenvironment/immunology*;
T-Lymphocytes, Regulatory/immunology*;
Neoplasms/therapy*;
Animals;
Lymphocytes, Tumor-Infiltrating/metabolism*
- From:
Chinese Medical Journal
2024;137(24):2996-3009
- CountryChina
- Language:English
-
Abstract:
Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells (Tconvs) has recently emerged as an important topic in antitumor therapy. In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment.
