Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds.
10.1097/CM9.0000000000003341
- Author:
Mingyu HAN
1
;
Feng WAN
2
;
Bin XIAO
3
;
Junrong DU
1
;
Cheng PENG
2
;
Fu PENG
1
Author Information
1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.
2. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.
3. Chengdu Push Bio-Technology Co., Ltd., Chengdu, Sichuan 610045, China.
- Publication Type:Review
- Keywords:
Cell components;
Lung adenocarcinoma;
Small-molecule compounds;
Tumor microenvironment
- MeSH:
Humans;
Tumor Microenvironment/drug effects*;
Adenocarcinoma of Lung/drug therapy*;
Lung Neoplasms/pathology*;
Adenocarcinoma/metabolism*;
Animals;
Apoptosis/physiology*
- From:
Chinese Medical Journal
2025;138(8):905-915
- CountryChina
- Language:English
-
Abstract:
Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix. The various cellular components exert a different role in apoptosis, metastasis, or proliferation of lung cancer cells through different pathways, thus contributing to the treatment of adenocarcinoma and potentially facilitating novel therapeutic methods. This review summarizes the research progress on different cellular components with cell-cell interactions in the TME of LUAD, along with their corresponding drug candidates, suggesting that targeting cellular components in the TME of LUAD holds great promise for future theraputic development.
