Recommendations for the timing, dosage, and usage of corticosteroids during cytokine release syndrome (CRS) caused by chimeric antigen receptor (CAR)-T cell therapy for hematologic malignancies.

Sanfang TU; Xiu LUO; Heng MEI; Yongxian HU; Yang LIU; Ping LI; Dehui ZOU; Ting NIU; Kailin XU; Xi ZHANG; Lugui QIU; Lei GAO; Guangxun GAO; Li ZHANG; Yimei FENG; Ying WANG; Mingfeng ZHAO; Jianqing MI; Ming HOU; Jianmin YANG; He HUANG; Jianxiang WANG; Yu HU; Weili ZHAO; Depei WU; Jun MA; Yuhua LI; Wenbin QIAN; Xiaojun HUANG; Weidong HAN; Aibin LIANG

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Recommendations for the timing, dosage, and usage of corticosteroids during cytokine release syndrome (CRS) caused by chimeric antigen receptor (CAR)-T cell therapy for hematologic malignancies.

Author: Sanfang TU ¹ ; Xiu LUO ² ; Heng MEI ³ ; Yongxian HU ⁴ ; Yang LIU ⁵ ; Ping LI ² ; Dehui ZOU ⁶ ; Ting NIU ⁷ ; Kailin XU ⁸ ; Xi ZHANG ⁹ ; Lugui QIU ⁶ ; Lei GAO ⁹ ; Guangxun GAO ¹⁰ ; Li ZHANG ⁷ ; Yimei FENG ⁹ ; Ying WANG ⁶ ; Mingfeng ZHAO ¹¹ ; Jianqing MI ¹² ; Ming HOU ¹³ ; Jianmin YANG ¹⁴ ; He HUANG ⁴ ; Jianxiang WANG ⁶ ; Yu HU ³ ; Weili ZHAO ¹⁵ ; Depei WU ¹⁶ ; Jun MA ¹⁷ ; Yuhua LI ¹ ; Wenbin QIAN ¹⁸ ; Xiaojun HUANG ¹⁹ ; Weidong HAN ⁵ ; Aibin LIANG ²
Author Information

1. Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China.
2. Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
3. Institute of Hematology, Union Hospital of Tongji Medical College; Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
4. Center for Bone Marrow Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
5. Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China.
6. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
7. Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
8. Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, China.
9. Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing 400037, China.
10. Department of Hematology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710000, China.
11. Tianjin First Central Hospital, The First Affiliated Central Hospital of Nankai University, The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.
12. Department of Hematology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
13. Department of Hematology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong 250012, China.
14. Department of Hematology, Changhai Hospital, The Naval Medical University, Shanghai 200433, China.
15. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics; National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
16. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
17. Department of Hematology, Harbin Institute of Hematology and Oncology, Harbin, Helongjiang 150081, China.
18. Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
19. National Clinical Research Center for Hematologic Disease, Peking University People's Hospital, Peking University Institute of Hematology, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, China.
Publication Type:Journal Article
From: Chinese Medical Journal 2024;137(22):2681-2683
CountryChina
Language:English