Interaction between macrophages and ferroptosis: Metabolism, function, and diseases.
10.1097/CM9.0000000000003189
- Author:
Qiaoling JIANG
1
;
Rongjun WAN
1
;
Juan JIANG
1
;
Tiao LI
1
;
Yantong LI
1
;
Steven YU
1
;
Bingrong ZHAO
1
;
Yuanyuan LI
1
Author Information
1. Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
- Publication Type:Review
- Keywords:
Ferroptosis;
Iron metabolism;
Macrophage;
Polarization
- MeSH:
Ferroptosis/physiology*;
Macrophages/metabolism*;
Humans;
Animals;
Iron/metabolism*;
Reactive Oxygen Species/metabolism*;
Lipid Peroxidation/physiology*;
Inflammation/metabolism*
- From:
Chinese Medical Journal
2025;138(5):509-522
- CountryChina
- Language:English
-
Abstract:
Ferroptosis, an iron-dependent programmed cell death process driven by reactive oxygen species-mediated lipid peroxidation, is regulated by several metabolic processes, including iron metabolism, lipid metabolism, and redox system. Macrophages are a group of innate immune cells that are widely distributed throughout the body, and play pivotal roles in maintaining metabolic balance by its phagocytic and efferocytotic effects. There is a profound association between the biological functions of macrophage and ferroptosis. Therefore, this review aims to elucidate three key aspects of the unique relationship between macrophages and ferroptosis, including macrophage metabolism and their regulation of cellular ferroptosis; ferroptotic stress that modulates functions of macrophage and promotion of inflammation; and the effects of macrophage ferroptosis and its role in diseases. Finally, we also summarize the possible mechanisms of macrophages in regulating the ferroptosis process at the global and local levels, as well as the role of ferroptosis in the macrophage-mediated inflammatory process, to provide new therapeutic insights for a variety of diseases.
