Hypotension with neurovascular changes and cognitive dysfunction: An epidemiological, pathobiological, and treatment review.
10.1097/CM9.0000000000003103
- Author:
Yingzhe CHENG
1
;
Lin LIN
1
;
Peilin HUANG
1
;
Jiejun ZHANG
1
;
Yanping WANG
2
;
Xiaodong PAN
1
Author Information
1. Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
2. Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
- Publication Type:Review
- MeSH:
Humans;
Hypotension/complications*;
Cognitive Dysfunction/etiology*;
Alzheimer Disease/epidemiology*;
Cerebrovascular Circulation/physiology*;
Cognition Disorders/etiology*
- From:
Chinese Medical Journal
2025;138(4):405-418
- CountryChina
- Language:English
-
Abstract:
Hypotension is a leading cause of age-related cognitive impairment. The available literature evidences that vascular factors are associated with dementia and that hypotension alters cerebral perfusion flow and can aggravate the neurodegeneration of Alzheimer's disease (AD). Despite the discovery of biomarkers and the recent progress made in neurovascular biology, epidemiology, and brain imaging, some key issues remain largely unresolved: the potential mechanisms underlying the neural deterioration observed in AD, the effect of cerebrovascular alterations on cognitive deficits, and the positive effects of hypotension treatment on cognition. Therefore, further well-designed studies are needed to unravel the potential association between hypotension and cognitive dysfunction and reveal the potential benefits of hypotension treatment for AD patients. Here, we review the current epidemiological, pathobiological, and treatment-related literature on neurovascular changes and hypotension-related cognitive dysfunction and highlight the unsettled but imminent issues that warrant future research endeavors.
