Association of lipid accumulation product, visceral adiposity index and endometriosis: A cross-sectional study from the 1999-2006 NHANES.
10.47102/annals-acadmedsg.2025170
- Author:
Yue HOU
1
;
Yingyi GUO
1
;
Jinshuang WU
1
;
Ning LOU
1
;
Dongxia YANG
2
Author Information
1. Heilongjiang University of Chinese Medicine, Harbin, China.
2. Gynaecology Department, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
- Publication Type:Review
- Keywords:
NHANES;
cross-sectional study;
endometriosis;
lipid accumulation product;
visceral adiposity index
- MeSH:
Humans;
Female;
Cross-Sectional Studies;
Endometriosis/metabolism*;
Adult;
Nutrition Surveys;
Intra-Abdominal Fat;
Lipid Accumulation Product;
Middle Aged;
Obesity, Abdominal/complications*;
Adiposity;
Risk Factors;
Logistic Models
- From:Annals of the Academy of Medicine, Singapore
2025;54(10):605-615
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Endometriosis (EMS) is a common gynaecological disorder linked to metabolic disturbances. However, evidence on the associations between lipid accumulation product (LAP) and visceral adiposity index (VAI) with the risk of EMS remains limited. This study aimed to explore the potential associations between LAP, VAI and EMS.
METHOD:Data were obtained from the 1999-2006 National Health and Nutrition Examination Survey (NHANES), including a total of 2046 samples. Weighted multivariable logistic regression models and smoothed curve fitting were used to assess the associations between LAP, VAI and EMS. Additionally, subgroup analyses and interaction tests were conducted to evaluate intergroup differences in the associations between LAP, VAI and EMS.
RESULTS:In the fully adjusted model, higher Log2 LAP (odds ratio [OR] 1.256, 95% confidence interval [CI] 1.102-1.431, P=0.0014) and Log2 VAI (OR 1.287, 95% CI 1.105-1.498, P=0.0022) were significantly associated with increased EMS risk. Participants in the highest quartile of Log2 LAP (OR 1.983, P=0.0029) and Log2 VAI (OR 1.690, P=0.0486) had a higher risk of EMS. Subgroup analysis showed stronger associations among women with diabetes (Log2 LAP OR 3.681, P=0.009; Log2 VAI OR 4.849, P=0.041).
CONCLUSION:Elevated LAP and VAI were independently associated with an increased risk of EMS. LAP and VAI may serve as potential indicators for assessing EMS-related risk, suggesting that visceral obesity and lipid metabolic disturbances might play roles in the pathophysiological process of EMS. These findings underscore the potential of LAP and VAI as non-invasive markers for EMS risk, warranting further validation in clinical settings.
