Research progress of effect mechanism of acupotomy for knee osteoarthritis.
10.13703/j.0255-2930.20250106-k0003
- Author:
Wenying YU
1
;
Jing LIU
1
;
Hong LIU
1
;
Liangzhi ZHANG
1
;
Zehao LIN
1
;
Zhongbiao XIU
2
Author Information
1. Department of Orthopedics and Traumatology, People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350004, China; First School of Clinical Medicine, Fujian University of TCM, Fuzhou
2. Department of Orthopedics and Traumatology, People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350004, China; Key Laboratory of Traditional Chinese Medicine Orthopedics and Sports Rehabilitation, Ministry of Education, Fujian University of TCM, Fuzhou 350122; Fujian Provincial Clinical Research Center for Chronic Musculoskeletal Diseases of Integrative Chinese and Western Medicine, Fuzhou
- Publication Type:English Abstract
- Keywords:
acupotomy;
knee osteoarthritis;
research progress;
therapeutic mechanism
- MeSH:
Humans;
Acupuncture Therapy;
Osteoarthritis, Knee/genetics*;
Animals
- From:
Chinese Acupuncture & Moxibustion
2025;45(6):867-874
- CountryChina
- Language:Chinese
-
Abstract:
Acupotomy therapy demonstrates the definite clinical efficacy on knee osteoarthritis (KOA). After reviewing systematically the mechanism studies on acupotomy for KOA over the past 5 years, It is revealed that acupotomy synergistically intervenes in the pathological progression of KOA through multi-target approaches, such as regulating cartilage homeostasis, restoring skeletal muscle function, alleviating synovial inflammatory responses, remodeling subchondral bone, and neuromodulation. But the current research still limits to single-tissue phenotypic observation, and is insufficiency in the in-depth exploration of multi-tissue synergistic interactions and molecular upstream-downstream regulatory mechanisms. Future studies should focus on the inheritance and innovation of acupotomy theory, and integrating multi-omics analytical technologies, artificial intelligence, and novel biochemical detection methods. The mechanism research targets on the interaction mechanisms among tissues, direct effects of acupotomy, immune-inflammatory regulatory mechanisms, and analgesic mechanisms, so as to comprehensively elucidate the therapeutic mechanism of acupotomy for KOA.
