Effect of transcutaneous electrical acupoint stimulation on postoperative pain in patients undergoing modified radical mastectomy for breast cancer.
10.13703/j.0255-2930.20240206-k0002
- Author:
Li YAN
1
;
Bin SUN
2
;
Meiyan ZHOU
2
;
Yan ZHANG
2
;
Fei GAO
3
;
Qianwen ZHAO
4
;
Liwei WANG
1
Author Information
1. Xuzhou Clinical School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China; Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province.
2. Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province.
3. Department of Acupuncture-Moxibustion and Encephalopathy, Xuzhou Hospital of TCM.
4. Xuzhou Clinical School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China.
- Publication Type:English Abstract
- Keywords:
breast cancer;
inflammatory factors;
modified radical mastectomy for breast cancer;
postoperative acute pain;
postoperative chronic pain;
randomized controlled trial (RCT);
transcutaneous electrical acupoint stimulation
- MeSH:
Humans;
Female;
Acupuncture Points;
Pain, Postoperative/blood*;
Middle Aged;
Breast Neoplasms/surgery*;
Adult;
Transcutaneous Electric Nerve Stimulation;
Mastectomy, Modified Radical/adverse effects*;
Interleukin-6/blood*;
Tumor Necrosis Factor-alpha/blood*;
Interleukin-10/blood*;
Aged
- From:
Chinese Acupuncture & Moxibustion
2025;45(2):162-166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative pain in patients undergoing modified radical mastectomy for breast cancer.
METHODS:A total of 140 female patients scheduled for unilateral modified radical mastectomy for breast cancer undergoing general anesthesia were randomized into a TEAS group (70 cases) and a sham TEAS group (70 cases, 2 cases dropped out). Patients in both groups received TEAS or sham TEAS at bilateral Neiguan (PC6), Zusanli (ST36), and Danzhong (CV17), respectively, from 30 min before anesthesia induction until the end of surgery, and on 1st, 2nd, and 3rd days after surgery for 30 min a time, once a day. On 1st, 2nd, and 3rd days after surgery, the pain visual analogue scale (VAS) score was observed; on 3, 6, 12 months after surgery, the incidence rate of chronic pain was observed; before surgery, and on 1st, 3rd, and 7th days after surgery, the serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10 were detected; the number of analgesia pump press, rescue analgesia, and the occurrence of adverse reaction after surgery were recorded in the two groups.
RESULTS:In the TEAS group, the VAS scores on 1st and 2nd days after surgery, and the incidence rates of chronic pain on 3 and 6 months after surgery were lower than those in the sham TEAS group (P<0.05). On 1st, 3rd, and 7th days after surgery, the serum levels of TNF-α, IL-6, and IL-10 were increased compared with those before surgery in both groups (P<0.05, P<0.01); the above indexes in the TEAS group were lower than those in the sham TEAS group (P<0.05). The number of analgesia pump press and the incidence rate of rescue analgesia after surgery in the TEAS group were lower than those in the sham TEAS group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions after surgery between the two groups (P>0.05).
CONCLUSION:TEAS can effectively improve both the postoperative acute pain and chronic pain in patients undergoing modified radical mastectomy for breast cancer, the mechanism may relate to inhibiting the inflammatory reaction.
