Analysis of the outcome indexes in randomized controlled trials of acupuncture and moxibustion for mild cognitive impairment.
10.13703/j.0255-2930.20240131-k0002
- Author:
Yuan QIN
1
;
Jinjie FU
2
;
Lingyong XIAO
1
;
Xinyu ZHANG
1
;
Huan YANG
1
;
Xiaoxuan WANG
1
;
Xiaoyu DAI
1
Author Information
1. First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China; National Clinical Medical Research Center of Acupuncture and Moxibustion of TCM, Tianjin
2. Graduate School of Tianjin University of TCM; School of TCM, Tianjin University of TCM.
- Publication Type:English Abstract
- Keywords:
acupuncture and moxibustion;
core outcome set;
mild cognitive impairment;
outcome indexes;
randomized controlled trial (RCT)
- MeSH:
Humans;
Acupuncture Therapy;
Cognitive Dysfunction/therapy*;
Moxibustion;
Quality of Life;
Randomized Controlled Trials as Topic;
Treatment Outcome
- From:
Chinese Acupuncture & Moxibustion
2024;44(12):1463-1471
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the outcome indexes of randomized controlled trials (RCTs) of acupuncture and moxibustion for mild cognitive impairment (MCI) so as to provide a reference for the protocol design and the construction of a core outcome set in relevant clinical trials of acupuncture and moxibustion for MCI.
METHODS:From CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library, EMbase, and Web of Science, RCTs of acupuncture and moxibustion for MCI were searched, and the time duration was ranged from January 1st, 2018 to October 31th, 2023. The general information and outcome indexes of the included studies were collected and analyzed through literature screening and data extraction.
RESULTS:A total of 46 studies were eligible, with 2 072 samples and 18 diagnostic criteria involved. The outcome indexes were categorized into 7 domains according to functional attributes, including clinical symptoms/signs, TCM symptoms/syndromes, physical and chemical examination, quality of life, psychiatric and mental health, safety assessment, and patient satisfaction. Eighty-four outcome indexes were reported, with the use frequency of 237. Currently, RCTs of acupuncture and moxibustion for MCI were limited in the big difference in neuropsychological assessment tool, the inadequate reports on educational degree/educational years, the diversity of physical and chemical detection indexes, the inconsistency of the time points for outcome evaluation, the insufficient application of primary and secondary outcomes, the lack of the application of TCM diagnosis, pattern/syndrome differentiation and outcomes, and the shortage in long-term prognosis and economic assessment.
CONCLUSION:It is recommended to specify and develop the core outcome set of acupuncture and moxibustion for MCI to advance the standardization of related research design, the rational selection of outcome indexes, and the reliability of the research results.
