Electroacupuncture at acupoints of liver meridian for diminished ovarian reserve of liver depression: a randomized controlled trial.
10.13703/j.0255-2930.20230905-k0005
- Author:
Qiuping LUO
1
;
Zhihong YANG
1
;
Lingmin JIN
1
;
Panbi CHEN
1
;
Yun JIANG
1
;
Qingke LI
1
;
Wei ZHANG
2
;
Xiaofang YANG
1
Author Information
1. College of Acupuncture-Moxibustion and Tuina, Guizhou University of TCM, Guiyang 550025, China.
2. Department of Acupuncture-Moxibustion, Tuina and Rehabilitation, First Affiliated Hospital of Hunan University of CM.
- Publication Type:English Abstract
- Keywords:
acupoints of the liver meridian;
diminished ovarian reserve;
electroacupuncture;
femoston;
liver depression;
randomized controlled trial (RCT)
- MeSH:
Humans;
Female;
Electroacupuncture;
Adult;
Acupuncture Points;
Meridians;
Ovarian Reserve;
Young Adult;
Liver Diseases/physiopathology*;
Liver/metabolism*;
Ovary/physiopathology*;
Treatment Outcome;
Depression/therapy*
- From:
Chinese Acupuncture & Moxibustion
2024;44(11):1261-1266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the therapeutic effect of electroacupuncture at acupoints of liver meridian in patients with diminished ovarian reserve (DOR) of liver depression.
METHODS:A total of 62 patients with DOR of liver depression were randomly divided into an electroacupuncture group (31 cases, 1 case discontinued) and a western medication group (31 cases, 1 case was eliminated). Electroacupuncture was applied at bilateral Taichong (LR 3), Ligou (LR 5), Ququan (LR 8), Jimai (LR 12) in the electroacupuncture group, with continuous wave, in frequency of 2 Hz and current of 0.5-1.0 mA, 30 min each time, once every other day, 3 times a week. Femoston was taken orally in the western medication group, oral estradiol tablets were taken for the first 14 days, followed by oral estradiol/progesterone complex tablets for the rest 14 days, 1 tablet a day. Both groups were treated for 3 consecutive menstrual cycles. Before and after treatment, the scores of TCM syndrome, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were observed, serum levels of follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) were detected, and antral follicle count (AFC), peak systolic velocity (PSV) and resistance index (RI) of ovarian artery were measured by color Doppler ultrasound in the two groups, and the clinical efficacy was evaluated after treatment.
RESULTS:After treatment, the scores of primary symptom and secondary symptom, as well as the total scores of TCM syndrome were decreased compared with those before treatment (P<0.01), the scores of SAS and SDS, as well as the serum FSH levels and RI of ovarian artery were decreased compared with those before treatment (P<0.01), while the serum AMH levels, AFC and PSV of ovarian artery were increased compared with those before treatment (P<0.05, P<0.01) in the two groups. After treatment, in the electroacupuncture group, the primary symptom score of TCM syndrome was higher than that in the western medication group (P<0.01), the secondary symptom score of TCM syndrome and the scores of SAS and SDS were lower than those in the western medication group (P<0.05, P<0.01). The total effective rate was 70.0% (21/30) in the electroacupuncture group and 73.3% (22/30) in the western medication group respectively, there was no significant difference in the total effective rate between the two groups (P>0.05).
CONCLUSION:Electroacupuncture at acupoints of liver meridian can effectively improve the clinical symptoms, anxiety and depression, regulate the serum sex hormone levels, increase AFC and improve ovarian blood supply in DOR patients of liver depression.
