Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology.
10.4103/singaporemedj.SMJ-2024-169
- Author:
Mayank DALAKOTI
1
;
Ching Kit CHEN
1
;
Ching-Hui SIA
1
;
Kian-Keong POH
2
Author Information
1. Cardiovascular Metabolic Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2. Department of Cardiology, National University Heart Centre, National University Health System, Singapore.
- Publication Type:Review
- MeSH:
Humans;
Atherosclerosis/diagnosis*;
Risk Factors;
Cardiovascular Diseases/prevention & control*;
Cholesterol, LDL/blood*;
Glycated Hemoglobin;
Cardiology/trends*;
Heart Disease Risk Factors
- From:Singapore medical journal
2025;66(3):141-146
- CountrySingapore
- Language:English
-
Abstract:
Subclinical atherosclerosis underlies most cardiovascular diseases, manifesting before clinical symptoms and representing a key focus for early prevention strategies. Recent advancements highlight the importance of early detection and management of subclinical atherosclerosis. This review underscores that traditional risk factor levels considered safe, such as low-density lipoprotein cholesterol (LDL-C) and glycated haemoglobin (HbA1c), may still permit the development of atherosclerosis, suggesting a need for stricter thresholds. Early-life interventions are crucial, leveraging the brain's neuroplasticity to establish lifelong healthy habits. Preventive strategies should include more aggressive management of LDL-C and HbA1c from youth and persist into old age, supported by public health policies that promote healthy environments. Emphasising early education on cardiovascular health can fundamentally shift the trajectory of cardiovascular disease prevention and optimise long-term health outcomes.
