Testicular tumours in children: a single-centre experience.
10.4103/singaporemedj.SMJ-2021-414
- Author:
Sajid ALI
1
;
Tariq LATIF
1
;
Muhammad Ali SHEIKH
1
;
Shazia PERVEEN
2
;
Muhammad BILAL
1
;
Albash SARWAR
1
Author Information
1. Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.
2. Department of Paediatric Surgery, Indus Medical College Hospital, Tando Muhammad Khan, Pakistan.
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
outcome;
paediatric;
primary testicular tumour
- MeSH:
Humans;
Male;
Testicular Neoplasms/mortality*;
Retrospective Studies;
Adolescent;
Child;
Child, Preschool;
Orchiectomy/methods*;
Chemotherapy, Adjuvant;
Treatment Outcome;
Neoplasm Staging;
Infant;
Endodermal Sinus Tumor/therapy*;
Neoplasms, Germ Cell and Embryonal
- From:Singapore medical journal
2025;66(6):321-326
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Testicular tumours in childhood have diverse characteristics for different age ranges. This study aimed to describe the pattern, presentation and outcomes of primary testicular tumours in a paediatric population.
METHODS:A retrospective study was conducted from January 2010 to December 2020 on children (≤18 years) with a diagnosis of primary testicular tumour. Baseline demographics, clinical characteristics, pathology, treatment and outcomes of these patients were analysed. The data were entered into IBM SPSS Statistics version 20.0. Chi-square test and Fisher's exact test were applied to find the statistical significance, which was set at P value ≤ 0.05.
RESULTS:The study included 115 males, with 85 (73.9%) patients in the prepubertal age range with a mean age of 2.53 ± 2.06 years and 30 (26.1%) patients in the postpubertal group with a mean age of 15.73 ± 1.25 years. Yolk sac tumour was the most common (62.6%) histological subtype. Majority (46.1%) of patients had stage I disease on presentation, while 29.6% had stage IV disease. All patients underwent upfront high inguinal radical orchiectomy, which was followed by platinum-based adjuvant chemotherapy in 67% of the patients. The five-year event-free survival and overall survival for all patients were 75% and 91%, respectively.
CONCLUSION:Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.
