The East Asian gut microbiome and its role in oncology: a narrative review.
10.4103/singaporemedj.SMJ-2022-042
- Author:
Evelyn Yi Ting WONG
1
;
Jonathan Wei Jie LEE
2
;
Jeremy Fung Yen LIM
2
;
Han Chong TOH
1
Author Information
1. Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
2. AMILI Pte Ltd, Singapore.
- Publication Type:Review
- Keywords:
Cancer immunotherapy;
East Asian microbiome;
gut microbiota;
microbiome modification;
onco-microbes
- MeSH:
Humans;
Gastrointestinal Microbiome;
Neoplasms/microbiology*;
Immunotherapy/methods*;
Asia, Eastern;
Medical Oncology;
Fecal Microbiota Transplantation;
Immune Checkpoint Inhibitors/therapeutic use*;
East Asian People
- From:Singapore medical journal
2025;66(8):426-430
- CountrySingapore
- Language:English
-
Abstract:
The field of onco-microbiome is rapidly expanding. Multiple studies have shown the crucial role of gut microbiota in the regulation of nutrient metabolism, immunomodulation and protection against pathogens. Tools for manipulating the gut microbiota include dietary modification and faecal microbiota transfer. Accumulating evidence has also documented the application of specific intestinal microbiome in cancer immunotherapy, notably in enhancing the efficacy of immune checkpoint inhibitors. The aim of this review is to focus on the East Asian microbiome and to provide a current overview of microbiome science and its clinical application in cancer biology and immunotherapy.
