Comparative Analysis of Clinic pathological Characteristics in Patients Undergoing Liver Resection
- VernacularTitle:Элэг тайруулах мэс засал хийлгэсэн өвчтөнүүдийн элэгний хорт хавдрын эмгэг судлалын зарим үр дүнгээс
- Author:
Unenbat G
1
;
Enkhtsatsral B
2
;
Bayart-Uils B
2
;
Ariyaboleg O
1
;
Tsersendorj D
1
;
Amgalantuul B
1
;
Batsaikhan B
1
;
Munkdelger B
1
;
Yerbolat A
1
;
Munkhzaya Ch
1
;
Lkham N
1
;
Chinburen J
1
;
Monkhtsetseg J
3
;
Gantuya D
4
Author Information
1. Hepatobiliary and Pancreatic Transplantation Center, National Cancer Center of Mongolia
2. Department of Pathology, National Cancer Center of Mongolia
3. Department of Biochemistry, School of Biomedicine, MNUMS
4. Department of Epidemiology and Biostatistics, School of Public Health, MNUMS
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma, ALD, MASH, HCC, Survival analysis, Pathology, Kaplan–Meier
- From:
Mongolian Journal of Health Sciences
2025;90(6):147-151
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide
and in Mongolia. Alcohol-related liver disease (ALD) and metabolic dysfunction-associated steatohepatitis (MASH) are
two major etiological factors contributing to the rising burden of HCC, each presenting distinct clinical and pathological
characteristics.
Aim:To compare the clinical, pathological, and survival characteristics of patients with ALD-related HCC and MASH-related HCC who underwent liver resection.
Material and Methods:A retrospective cohort study was conducted using clinical and pathological data from 980 patients who underwent liver resection between 2010 and 2024. Among them, 191 were categorized into the ALD group and
789 into the MASH group. Clinical parameters, laboratory findings, tumor pathology (size, grade, fibrosis stage, vascular
invasion), recurrence, and overall survival (OS) were analyzed. A simulated Kaplan–Meier survival curve was generated
based on group-level survival estimates.
Results:Patients with ALD were significantly younger and predominantly male compared with those in the MASH group
(p=0.0014; p<0.0001). The MASH group demonstrated more aggressive pathological features, including larger tumors
(>5 cm), poorer differentiation (G3–4), advanced T4 stage, and a higher rate of large-vessel invasion (all p<0.05). Despite
these findings, the MASH group showed a longer mean overall survival (92.6 months) than the ALD group (82.0 months;
p=0.0206).
Conclusion:Although MASH exhibits more aggressive pathological features compared with ALD, patients in the MASH
group demonstrated better overall survival. These findings underscore the importance of incorporating etiological differences into the diagnostic, therapeutic, and postoperative management strategies for HCC.
- Full text:2025121111014992548Элэг тайруулах мэс засал хийлгэсэн өвчтөнүүдийн элэгний хорт хавдрын эмгэг судлалын зарим үр дүнгээс.pdf
