Rare presentation of malignant melanoma as qauda equna syndrome from intradural extramedullary metastasis
- VernacularTitle:Адуун сүүлний хам шинжээр илэрсэн меланомын интрадурал эксрамедулляр үсэрхийллийн ховор тохиолдол
- Author:
Bayardelger J
1
;
Lkhamgvasuren S
2
;
Gantsetseg P
3
;
Nandinbayar M
1
;
Lkhamtsoo N
1
Author Information
1. Third State Central Hospital
2. Medtrauma hospital
3. National Pathology Center
- Publication Type:Case Reports
- Keywords:
Brain and spinal metastasis, Late recurrence, Leptomeningial disease.
- From:
Mongolian Journal of Health Sciences
2025;90(6):222-228
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:The incidence of metastatic melanoma (MM) has been steadily rising, and it is the third most common
metastatic lesion to the central nervous system. Spinal intradural extramedullary MM is rare, and it is associated with
coexisting or antecedent brain metastasis.
A 66-year-old patient presented to us with a seizure, malaise, low back pain, progressive weakness of both lower limbs,
and bladder dysfunction. She had a known history of MM of the brain, which was diagnosed just 5 months before the
current presentation. 5 months ago, she was admitted to the Neurosurgery clinic and underwent an excision of one of three
metastases in the brain. The histopathological findings were consistent with malignant melanoma that was confirmed with
immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). The patient underwent an extensive
magnetic resonance imaging scan of the brain and lumbosacral region that suggested T1 hyperintense, T2 hypointense,
intradural extramedullary altered signal intensity lesions at the cauda equina region as well as widespread leptomeningeal
disease.
Here, we are discussing an unusual case with a comprehensive review regarding the pathogenesis, diagnosis, and prognosis
of the tumor.
Conclusion:Brain metastasis from melanoma is associated with a poor prognosis, with an average survival of only 4–6
months after diagnosis. Leptomeningeal metastasis and extramedullary metastatic involvement indicate the terminal stage
of the disease. Although the overall prognosis remains unfavorable, emerging mechanism-based therapies have improved
survival and quality of life for some patients. Nevertheless, early diagnosis of melanoma remains the key factor in improving
patient outcomes.
- Full text:2025121016015004339Адуун сүүлний хам шинжээр илэрсэн меланомын интрадурал эксрамедулляр үсэрхийллийн ховор тохиолдол.pdf
