A study of complications in recipients with early kidney dysfunction after liver transplantation
- VernacularTitle:Элэг шилжүүлэн суулгах мэс заслын дараах эрт үеийн бөөрний үйл ажиллагааны алдагдалтай эмчлүүлэгчдийн хүндрэлийг судалсан нь
- Author:
Batsaikhan B
1
;
2
;
3
;
Shiirevnyamba A
1
;
2
;
Tserenbat B
3
;
Bayarbileg G
3
;
Bat-Ireedui B
3
;
Ariunaa T
4
;
Sergelen O
1
;
3
Author Information
1. Department of Surgery, School of Medicine, MNUMS
2. Graduate School, MNUMS
3. The Transplantation Center, FCHM
4. Department of Nephrology, MNUMS
- Publication Type:Journal Article
- Keywords:
Liver transplantation, Kidney dysfunction, Postoperative complications, Outcomes
- From:
Mongolian Journal of Health Sciences
2025;89(5):150-157
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Liver transplantation (LT) recipients frequently develop complication kidney dysfunction (KD), but the
predisposing factors and long-term consequences of KD are not well understood. Post-LT complications that lead to graft
failure and patient morbidity/mortality can be generally categorized as vascular, biliary, parenchymal and malignant.
Main reasons for our study are to identify complications’ rate for early post-transplant KD and to evaluate the post-LT
patients and graft survival rate.
Aim:Our aim was to evaluate complications in recipients with early post-transplant KD and to investigate the survival
rate after LT.
Material and Methods:This study retrospectively and prospectively analyzed the demographic characteristics, preoperative
and perioperative clinical parameters, as well as postoperative outcomes of patients who underwent liver transplantation
(LT) at the First Central Hospital of Mongolia (FCHM) between September 2011 and December 2024. Renal
function was evaluated by estimating the glomerular filtration rate (GFR) using the Cockcroft-Gault creatinine clearance
formula at baseline (pre-transplantation) and at 24 hours, 72 hours, 7 days, 14 days, and 28 days following LT. Early
and late complications following LT were classified according to the international classification. Ethical approval for the
study was obtained at a meeting of the Research Ethics Review Board of the Mongolian National University of Medical
Sciences (MNUMS).
Results:In our study KD rate was 29.7%. Several factors increased the risk of KD among recipients. Post-LT complications’
related risk factors for KD was high MELD score (OR, 1.11; 95%CI, 1.06-1.16), Child-Turcotte-Pugh scores of B
and C (OR, 5.57; 95%CI, 1.27-24.52 and OR, 8.21; 95%CI, 1.87–36.54), comorbidities (OR, 1.92; 95%CI, 1.14-3.23),
post-LT acute bleeding (OR, 3.22; 95%CI, 1.22-8.46), early relaparotomy for revision (OR, 3.12; 95%CI, 1.34-7.28
respectively. Additionally, the survival rates for recipients with post-LT KD were 90.7% at 1 year and 81.3% at 3 years.
Conclusions:1. Variables like a recipient high age (p<0.001), female gender (p<0.001), elevated liver function scores (p<0.002),
comorbidities (p=0.013), severe ascites (p=0.001), preop intensive care (p=0.026) are pre-LT risk factors for post-
LT KD.
2. Acute bleeding (p=0.013), early revision (p=0.006) are risk factors for post-LT KD.
3. Early KD in recipients who underwent LT affects both patient survival (Log Rank p=0.522; HR 1.3) and graft
survival (Log Rank p=0.457; HR 1.26).
- Full text:2025121012080090786Элэг шилжүүлэн суулгах мэс заслын дараах эрт үеийн бөөрний үйл ажиллагааны алдагдалтай.pdf
