Effect of flavanone on the migration of lung cancer cells
- VernacularTitle:Уушгины хавдрын эсийн нүүн шилжилтэд флаваноны нөлөөг судалсан дүн
- Author:
Jadamba Ch
1
;
2
;
Erdenezaya O
3
;
Iderjavkhlan S
2
;
Burnee M
2
;
Gurbadam A
2
;
Temuulen D
2
;
Darambazar G
2
;
Oldokh O
4
;
Enkhmaa D
4
;
Giimaa N
2
Author Information
1. Department of basic Medical Education, School of Medicine, Darkhan-Uul
2. Department of Biology, School of BioMedicine, MNUMS
3. Department of Anatomy, School of BioMedicine, MNUMS
4. Department of Chemistry, School of BioMedicine, MNUMS
- Publication Type:Journal Article
- Keywords:
5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone, A549 cell line, Migration
- From:
Mongolian Journal of Health Sciences
2025;89(5):129-132
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In recent years, natural compounds have been shown to play an important role in cancer prevention and
early-stage therapy. Flavanones, a class of polyphenolic compounds present in plants, vegetables, seeds, fruit peels, and
flowers, have been identified to possess anticancer, antioxidant, anti-inflammatory, and antibacterial bioactivities. Cancer
has become a major global economic and public health challenge. According to international statistics, one in four individuals
(22.8%) die from non-communicable diseases, while one in six (16.8%) die from cancer.
Aim:To investigate the effect of flavanone (5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) isolated from Iris tenuifolia
on the migration of lung cancer cells.
Materials and Methods:The study was conducted at the Institute of Biomedicine, MNUMS. The effect of flavanone
(5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) on cancer cell migration was evaluated in vitro using the scratch assay.
Human lung cancer cells (A549) were revived and stabilized before experiments were performed.
Results:We treated A549 cancer cells with different concentrations of flavanone (1.25 μg/ml, 2.5 μg/ml) for 24 hours
and analyzed them using the scratch assay. A cell-free gap of 0.9 mm in width was created, and after 24 hours, A549 cells
migrated and proliferated into the gap, reducing its width to 0.25 mm. Treatment with 2.5 μg/ml flavanone completely
inhibited cell migration.
Conclusion:Flavanone isolated from Iris tenuifolia inhibits lung cancer cell migration in a doseand
time-dependent manner.
- Full text:202512101132257009Уушгины хавдрын эсийн нүүн шилжилтэд флаваноны нөлөөг судалсан дүн.pdf
