Effects of Shimshin-6 on postpartum uterine involution in rats
- VernacularTitle:Төрсний дараах умайн эргэн хөгжилд Шимшин-6 эмийн үзүүлэх нөлөөг туршилтын амьтанд судалсан дүн
- Author:
Nomin-Erdene J
1
;
2
;
Dejidmaa B
3
;
Erdenechimeg Ch
3
;
Munkhtsetseg D
4
;
Chimedragchaa Ch
3
Author Information
1. Department of Traditional Prescriptionology, International School of Mongolian Medicine, MNUMS
2. Department of Clinical, Darkhan-Uul Medical School, MNUMS
3. Research center, Institute of Traditional Medicine and Technology
4. Department of Obstetrics and Gynecology, School of Medicine, MNUMS
- Publication Type:Journal Article
- Keywords:
Uterine weight, Estrogen, TGF-β1, TGF-β3, Traditional medicine
- From:
Mongolian Journal of Health Sciences
2025;89(5):95-99
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:The Shimshin-6 formulation, composed of Rheum undulatum L., Hippophae rhamnoides L., Zingiber
officinale Roscoe, Saussurea lappa C.B. Clarke, Sal ammoniacum, and Tronae veneni, has traditionally been used in the
management of gynecological disorders such as amenorrhea, abnormal blood clot formation, and pelvic pain. It has also
been widely applied in postpartum care to promote uterine contractility and to prevent complications, including hemorrhage
and inflammation. However, its therapeutic potential in postpartum uterine involution has not been scientifically
validated.
Aim:To investigate the effects of the Shimshin-6 herbal formulation on postpartum uterine involution in rats
Materials and Methods:This experimental study was conducted at the Research Center of the Institute of Traditional
Medicine and Technology, following the methodology described by Zheng ZH et al. (2019). Postpartum rats were randomly
assigned to four groups and received daily treatments for five consecutive days with either Shimshin-6 tablets at
doses of 180 mg/kg and 90 mg/kg, Shimshin-6 decoction at 163 mg/kg, or physiological saline as a control. Serum concentrations
of estrogen, progesterone, TNF-α, TGF-β1, and TGF-β3 were measured using commercially available ELISA
kits (Shanghai MLBIO Biotechnology Co. Ltd, China). Following ethical euthanasia, uterine tissues were collected for
histological examination, which included evaluation of uterine weight, endometrial thickness, myometrial structure, and
glandular morphology.
Results:Shimshin-6 treatment significantly reduced the uterine index and serum estrogen levels compared with the
control group, while no significant difference was observed in progesterone concentration. The treatment also decreased
tumor necrosis factor-α (TNF-α) levels and modulated growth factors in postpartum rats. Histological analysis further revealed
that Shimshin-6 promoted uterine recovery, despite the presence of inflammatory cell infiltration and hemorrhagic
changes in the uterine wall.
Conclusion:Shimshin-6 preparation exerts a promotive effect on postpartum uterine involution in rats.
- Full text:2025121010415966989Төрсний дараах умайн эргэн хөгжилд Шимшин-6 эмийн үзүүлэх нөлөөг туршилтын амьтанд.pdf
