Serum levels of Aquaporin-4, IL-6, and TNF-α in Patients with Primary Brain Tumors
- VernacularTitle:Тархины анхдагч хавдрын үед ийлдэс дэх Aquaporin-4, IL-6, TNF-α-ийн түвшинг тодорхойлсон дүн
- Author:
Baigalmaa D
1
;
Orkhontuul Sh
2
;
Enkhtuya S
3
;
Tsogtsaikhan S
1
;
Gansukh Ch
1
;
Enkhsaikhan L
1
;
4
;
Ariunzaya B
1
;
5
Author Information
1. Department of Immunology, School of Biomedicine, MNUMS
2. The Department of Neurosurgery, The Third State Central Hospital of Mongolia
3. Central Scientific Research Laboratory, Institute of Medical
4. Laboratory of Immunobiology, Institute of Biomedical Sciences, MNUMS
5. Department of Health Research, Graduate School of Mongolian National University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Glioma, Glioblastoma, biomarker, Anti-inflammatory cytokine, Water channel protein
- From:
Mongolian Journal of Health Sciences
2025;89(5):79-84
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Gliomas are common primary brain tumors of glial origin in adults with a poor prognosis. Tumor-related
inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and aquaporin-4 (AQP-4)
water channel protein have been reported to be expressed in gliomas
Aim:This study aimed to determine their serum levels in patients with primary brain tumors compared to healthy controls
and to evaluate their potential diagnostic value.
Materials and Methods:Serum AQP-4 levels were measured by ELISA in 28 patients with primary brain tumors (PBT)
and 26 healthy controls. IL-6 and TNF-α were assessed by flow cytometry in 59 PBT patients and 52 controls.
Results:Among the primary brain tumor cases, 45.61% were meningiomas, 26.32% anaplastic astrocytomas, 8.77%
glioblastomas, and 12.28% other tumors (including chondroma, ependymoma, schwannoma, craniopharyngioma). Serum
IL-6, TNF-α, and AQP-4 levels were significantly higher in the PBT group compared with healthy controls.
Conclusion:Elevated serum levels of AQP-4, IL-6, and TNF-α in patients with primary brain tumors suggest that these
biomarkers molecules could represent valuable non-invasive biomarkers for the early detection of PBT.
- Full text:2025121010275896826Тархины анхдагч хавдрын үед ийлдэс дэх Aquaporin-4, IL-6, TNF-α-ийн түвшинг.pdf
