Analysis of the effect of intraocular injection of recombinant tissue plasminogen activator on pars plana vitrectomy outcomes in patients with rupture of the globe
10.3980/j.issn.1672-5123.2025.12.29
- VernacularTitle:r-TPA眼内注射对眼球破裂伤患者玻璃体切割手术效果影响分析
- Author:
Shaoxi ZHUANG
1
;
Zhengxia XIAO
1
;
Beibei HAN
1
;
Jianwei LIU
1
Author Information
1. Shandong Second Medical University, Weifang 261053, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
rupture of the globe;
recombinant tissue plasminogen activator(r-TPA);
pars plana vitrectomy.
- From:
International Eye Science
2025;25(12):2052-2055
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of intravitreal injection of recombinant tissue plasminogen activator(r-TPA)before pars plana vitrectomy(PPV)on surgical outcomes in patients with rupture of the globe(RG).METHODS: A retrospective study was conducted on 37 patients(37 eyes)with RG who underwent PPV 7-10 d after Stage Ⅰ suturing and stabilization at our hospital between April 2020 and November 2023. Based on whether an intravitreal r-TPA injection was administered 1 d before PPV, patients were divided into two groups, with 14 cases(14 eyes)in pre-operative r-TPA injection group, and 23 cases(23 eyes)in control group without pre-operative r-TPA injection. The intraoperative retinal reattachment rate, intraoperative silicone oil application, postoperative intraocular rebleeding, postoperative hypotony, and best-corrected visual acuity(BCVA)were compared between the two groups.RESULTS: The baseline characteristics were comparable between the two groups(P>0.05). Significant differences were found between the two groups in the intraoperative retinal reattachment rate, the volume of silicone oil injected, and the proportion of BCVA(all P<0.05). No statistically significant differences were observed in the intraoperative silicone oil tamponade rate, postoperative intraocular rebleeding, or postoperative hypotony rates(all P>0.05).CONCLUSION: RG patients who received an intravitreal r-TPA injection 1 d before PPV demonstrated significantly higher intraoperative retinal reattachment rates and better postoperative visual acuity outcomes.
