Correlation of C-reactive protein-to-albumin ratio and neutrophil-to-lymphocyte count ratio with the pathological stage and prognosis of retinopathy of prematurity
10.3980/j.issn.1672-5123.2025.12.20
- VernacularTitle:CAR和NLR水平与早产儿视网膜病变病理分期及预后的相关性
- Author:
Dongxing ZHANG
1
;
Yajing LIU
1
;
Yihan ZHANG
1
;
Yueming GE
1
Author Information
1. Department of Ophthalmology, Tangshan Maternal and Children Health Hospital, Tangshan 063000, Hebei Province, China
- Publication Type:Journal Article
- Keywords:
retinopathy of prematurity;
C-reactive protein-to-albumin ratio(CAR);
neutrophil-to-lymphocyte count ratio(NLR);
pathological staging;
prognosis
- From:
International Eye Science
2025;25(12):2005-2010
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the correlation of serum C-reactive protein(CRP)-to-albumin(ALB)ratio(CAR)and neutrophil-to-lymphocyte count ratio(NLR)with pathological staging and prognosis of retinopathy of prematurity(ROP), and the predictive value of its combined testing for the prognosis of infants.METHODS:Prospective study. A total of 147 children with ROP who were born in our hospital from March 2022 to September 2024 were served as the ROP group, and 100 premature infants without ROP were served as the control group in the same period. Fully automatic biochemical analyzer was used to detect serum CRP and ALB; the flow cytometry nucleic acid fluorescence staining was used to count neutrophils and lymphocytes, and the CAR and NLR were calculated. Spearman correlation was used to analyze the relationship of serum CAR and NLR with ROP staging. Logistic regression was used to analyze the factors affecting the prognosis of children with ROP. ROC curve was drew to analyze the predictive value of serum CAR and NLR for the prognosis of ROP.RESULTS: There was comparability between the ROP group and the control group. The ROP group had significantly higher serum CRP, CAR, neutrophil count, and NLR than the control group, and clearly lower ALB and lymphocyte count than the control group(all P<0.05). Children with stage IV ROP had clearly higher serum CAR and NLR than stages I, II, and III, and the differences among stages I, II, and III were significant(all P<0.05). Serum CAR and NLR were positively correlated with ROP staging(r=0.529, 0.587, all P<0.05), and there was a positive correlation between serum CAR and NLR(r=0.546, P<0.05). The poor prognosis group had clearly higher serum CAR and NLR than good prognosis group(all P<0.001). Elevated serum CAR and NLR were risk factors affecting the prognosis of children with ROP(all P<0.05). The AUC of serum CAR, NLR, and joint detection in predicting the prognosis of ROP children was 0.803, 0.825, and 0.938, respectively. The joint detection showed better predictive performance(Zcombinatoion-CAR=2.637, Zcombinatoion-NLR=2.528, all P<0.05).CONCLUSION:Serum CAR and NLR are elevated in children with ROP, and they are closely related to pathological staging and prognosis. The joint detection has a higher predictive value in evaluating the prognosis of ROP.
