Regulatory mechanism and therapeutic targets of mitogen-activated protein kinase signaling pathway in retinal diseases
10.3980/j.issn.1672-5123.2025.12.14
- VernacularTitle:MAPK信号通路在视网膜疾病中的调控机制和治疗靶点
- Author:
Yue HE
1
;
GERILETU
1
Author Information
1. Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China; Department of Ophthalmology, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, Inner Mongolia Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
mitogen-activated protein kinase(MAPK)signaling pathway;
retinal diseases;
regulatory mechanism;
therapeutic target
- From:
International Eye Science
2025;25(12):1973-1978
- CountryChina
- Language:Chinese
-
Abstract:
The retina is an important component in the formation of vision. Retinal diseases affect normal vision. The mitogen-activated protein kinase(MAPK)signaling pathway is widely expressed in biologically active cells. The MAPK signaling pathway plays a pivotal role in regulating key physiological processes, including cell growth, proliferation, differentiation and apoptosis. Recent studies have shown that the MAPK signaling pathway is involved in the pathogenesis of retinal diseases, including pathological processes such as inflammatory responses, oxidative stress, and abnormal vascular formation. This article aims to summarize the regulatory mechanism of the MAPK signaling pathway in the occurrence and development of retinal diseases, such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and other diseases. Exploring the MAPK pathway's potential as a therapeutic target may provide new insights and strategies for clinical treatment.
