Clinical features and potential association of choroidal neovascularization with focal choroidal excavation
10.3980/j.issn.1672-5123.2025.12.13
- VernacularTitle:伴发局灶性脉络膜凹陷的脉络膜新生血管的临床特征及潜在关联
- Author:
Min YANG
1
;
Fengzhi LI
1
;
Xiangxia LUO
1
;
Hongqiang WANG
1
Author Information
1. Department of Ophthalmology, Qingyang Hospital of Traditional Chinese Medicine, Qingyang 745100, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
choroidal excavation;
choroidal neovascularization;
potential association
- From:
International Eye Science
2025;25(12):1969-1972
- CountryChina
- Language:Chinese
-
Abstract:
Focal choroidal excavation(FCE)is an elusive clinical sign characterized by a localized structural depression in the choroid. It has been increasingly recognized with the widespread use of optical coherence tomography(OCT), though its pathogenesis remains incompletely understood and may involve congenital developmental anomalies or acquired factors(such as inflammation or tumor compression). Studies indicate that FCE can occur independently or secondary to various chorioretinal diseases(e.g., central serous chorioretinopathy, choroidal osteoma, age-related macular degeneration, etc.). Clinically, it has also been observed that FCE may be associated with the development of choroidal neovascularization(CNV). Potential mechanisms linking FCE and CNV include: 1)mechanical traction-hypoxia-signaling pathway activation; 2)disruption of the retinal pigment epithelium(RPE)-Bruch's membrane-choroid complex barrier; 3)structural collapse induced by inflammatory scar contraction. Anti-vascular endothelial growth factor(VEGF)therapy is currently the mainstay of treatment for CNV secondary to FCE. By reviewing relevant domestic and international literature, this paper seeks to elucidate the possible pathological relationship between FCE and CNV, with the goal of facilitating early identification of high-risk patients and optimizing anti-VEGF treatment strategies. It also highlights the limitations of current research(such as sample heterogeneity and lack of histological validation of typing criteria), and suggests future directions, such as multicenter studies and molecular mechanism investigations, to support the development of personalized diagnostic and therapeutic approaches.
